Schistosoma spp.
Schistosoma spp.
MATERIAL SAFETY DATA SHEET – INFECTIOUS SUBSTANCES
SECTION I – INFECTIOUS AGENT
NAME: Schistosoma spp.
SYNONYM OR CROSS REFERENCE: Schistosoma mansoni, S. japonicum, S. haematobium, Bilharziasis, Snail fever, Schistosomiasis
CHARACTERISTICS: Trematode, flatworm, blood flukes; two distinct sexual forms; adult worms are 12-16 mm in length and 0.3-0.6 mm in width, male worms are shorter thicker than the longer slender females; eggs are round or oval and the size varies within species; cercariae (infective larva) are 400-600 µm in length, and contain a pear-shaped head and a forked tail
SECTION II – HEALTH HAZARD
PATHOGENICITY: Symptoms are related to amount and location of eggs in the human host; infections with Schistosoma mansoni and S. japonicum results in primarily hepatic and intestinal symptoms including diarrhea, abdominal pains, and hepatosplenomegaly; S. haematobium produces urinary manifestation including dysuria and hematuria; important complications that arises from chronic infections includes liver fibrosis, portal hypertension and possibly colorectal malignancy in the intestinal form; also CNS manifestations can occur; papular rash can result at points of entry by cercariae in these and other Schistosoma spp. (swimmer’s itch)
EPIDEMIOLOGY: S. mansoni is found in Africa, the Arabian Peninsula, Brazil, Surinam and Venezuela and some Caribbean islands; S. haematobium is found in Africa, and the Middle East; S. japonicum is found China, Japan, the Philippines and Indonesia; an estimated 500-600 million people are infected in 75 countries; geographic distribution of schistosomiasis confined to an area between 36 degree north and 34 degree south latitude, where freshwater temperature averages 25-30° C; distribution of each species is dependant on the presence of an appropriate snail population
HOST RANGE: Principally humans for S. haematobium and S mansoni; humans, dogs, cats, pigs, cattle, water buffalo, horses, and rodents in S. japonicum
INFECTIOUS DOSE: Not known
MODE OF TRANSMISSION: Mainly by contact with contaminated water. Infective free-swimming larval forms (cercariae) penetrate directly through the skin
INCUBATION PERIOD: 2-6 weeks after exposure
COMMUNICABILITY: Not directly transmitted from person-to-person; infective person will release eggs in urine and feces; infective snails will release cercariae as long as they live (several weeks to 3 months)
SECTION III – DISSEMINATION
RESERVOIR: Humans, cats, dogs, cattle, horses, water buffalo, pigs, rodents
ZOONOSIS: animals serve as reservoirs, possible role in the indirect spread of the disease
VECTORS: Snails – Bulinus spp. for S. haematobium
Biomphalaria spp. for S. mansoni
Onocomelania spp. for S. japonicum
SECTION IV – VIABILITY
DRUG SUSCEPTIBILITY: All are sensitive to praziquantel, oxamniquine can be used for S. mansoni, and metrifonate can be used to treat S. japonicum
SUSCEPTIBILITY TO DISINFECTANTS: All infective stages are susceptible to 2% glutaraldehyde, 1% sodium hypochlorite: 70% ethanol will inactivate surface cercariae
PHYSICAL INACTIVATION: Sensitive to freezing
SURVIVAL OUTSIDE HOST: Not known
SECTION V – MEDICAL
SURVEILLANCE: Monitor for symptoms; confirm by parasitologic examination of excrement or serological analysis
FIRST AID/TREATMENT: Administer appropriate drug therapy
IMMUNIZATION: None available
PROPHYLAXIS: None available
SECTION VI – LABORATORY HAZARDS
LABORATORY-ACQUIRED INFECTIONS: One case was documented up to 1987
SOURCES/SPECIMENS: Feces, biopsy specimens, urine
PRIMARY HAZARDS: Ingestion; cercariae-containing droplet exposure to the skin or mucous membranes
SPECIAL HAZARDS: Hand to mouth transfer of metacercariae following contact with contaminated aquatic vegetation
SECTION VII – RECOMMENDED PRECAUTIONS
CONTAINMENT REQUIREMENTS: Biosafety level 2 practices and containment facilities for all activities involving the infective stages of the parasite and potentially infectious body tissues or fluids
PROTECTIVE CLOTHING: Laboratory coat; gloves when skin contact with infectious materials is unavoidable
OTHER PRECAUTIONS: Travelers should avoid contact with bodies of fresh water in endemic areas
SECTION VIII – HANDLING INFORMATION
SPILLS: Allow aerosols to settle; wearing protective clothing gently cover the spill with absorbent paper towel and apply 1% sodium hypochlorite starting at the perimeter and working towards the center; allow sufficient contact time (30 min) before clean up
DISPOSAL: Decontaminate all wastes before disposal; steam sterilization, incineration, chemical disinfection
STORAGE: In sealed containers that are appropriately labelled
SECTION IX – MISCELLANEOUS INFORMATION
Date prepared: March, 2001
Prepared by: Office of Laboratory Security, PHAC
Although the information, opinions and recommendations contained in this Material Safety Data Sheet are compiled from sources believed to be reliable, we accept no responsibility for the accuracy, sufficiency, or reliability or for any loss or injury resulting from the use of the information. Newly discovered hazards are frequent and this information may not be completely up to date.
Copyright © Health Canada, 2001
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